The developmental and overall health benefits of breastfeeding must be deemed combined with the mother's clinical need for oxycodone HCl and any opportunity adverse results within the breastfed toddler from oxycodone HCl or in the underlying maternal ailment.

Multiply total everyday dose of prior opioid with the conversion factor (CF) provided down below to acquire oxycodone dose in mg/working day; divide oxycodone mg/working day dose by 2 to receive twelve-hour oxycodone ER dose; if rounding is important, often round down to the nearest tablet strength offered

If concomitant use is warranted, meticulously observe the patient, especially in the course of therapy initiation and dose adjustment. Discontinue oxycodone HCl if serotonin syndrome is suspected.

Hypotension Notify patients that oxycodone HCl may possibly bring about orthostatic hypotension and syncope. Instruct patients how to recognize signs and symptoms of minimal blood pressure and the way to lower the risk of severe implications need to hypotension manifest (e.

Drink Alcoholic beverages or use prescription or over-the-counter medicines that include Liquor. Using merchandise containing Alcoholic beverages during treatment method with oxycodone HCl tablets may well bring about you to overdose and die.

Cytochrome P450 3A4 Interaction The concomitant use of oxycodone with all cytochrome P450 3A4 inhibitors may possibly result in an increase in oxycodone plasma concentrations, which could boost or extend adverse reactions and will lead to most likely fatal respiratory melancholy.

You shouldn't use OxyContin Except you're presently using the same opioid medicine and they are tolerant to it.

When discontinuing oxycodone HCl, progressively taper the dosage employing a individual-certain approach that considers the subsequent: the dose of oxycodone HCl the individual has been using, the duration of therapy, as well as the Actual physical and psychological attributes from the client. To improve the probability of An effective taper and lessen withdrawal signs or symptoms, it can be crucial that the opioid tapering schedule is agreed upon via the client.

Dose conversions must be finished thoroughly and with close checking as a consequence of large patient variability in opioid analgesic reaction; discontinue all other within the clock opioid medications when initiating ER read more therapy.

Opioid medicines, which includes this medication, can sluggish or end your respiration, and death may possibly take place. An individual caring for you'll want to give naloxone and/or find crisis professional medical awareness When you have slow respiratory with extensive pauses, blue-coloured lips, or In case you are challenging to awaken.

Warn clients not to drive or work hazardous equipment Unless of course They may be tolerant to the results of oxycodone HCl and know the way they may respond for the medication [see Individual Counseling Information and facts (17)].

Since OxyContin is useful for discomfort, you are not likely to miss out on a dose. Skip any missed dose if it is almost time for your personal future dose. Never use two doses at a single time.

Acute or extreme bronchial asthma or hypercarbia in an unmonitored placing or from the absence of resuscitative machines

Driving or Functioning Machinery Advise patients that oxycodone HCl might impair a chance to perform probably harmful functions for instance driving a vehicle or running dangerous machinery.